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An improved biofunction of titanium for keratoprosthesis by hydroxyapatite-coating.
Ying Dong1, Jingxin Yang, Liqiang Wang
11Department of Ophthalmology, The First Affiliated Hospital, Chinese PLA General Hospital, Beijing, China.
Journal of Biomaterials Applications
|June 11, 2013
Summary
Nanostructured hydroxyapatite coating on titanium improves tissue integration for keratoprosthesis implants. This novel approach reduces tissue melting and enhances stability in corneal blindness treatment.
Area of Science:
- Biomaterials Science
- Ophthalmology
- Tissue Engineering
Background:
- Titanium keratoprosthesis is used for severe corneal blindness.
- Frequent tissue melting around titanium implants is a significant clinical challenge.
Purpose of the Study:
- To coat titanium with nanostructured hydroxyapatite (HA) using aerosol deposition.
- To evaluate the coating's characteristics and biological performance for improved tissue integration.
Main Methods:
- Characterization of nanostructured HA coating using XRD, SEM, AFM, and Auger spectroscopy.
- In vitro evaluation of rabbit cornea fibroblast adhesion.
- In vivo assessment of implant stability and tissue response in a rabbit corneal model.
Main Results:
- The nanostructured HA coating exhibited a grain-like surface and good substrate adhesion.
- Rabbit cornea fibroblasts showed good adhesion to the nanostructured HA surface in vitro.
- Implants demonstrated stable retention in rabbit corneas in vivo, with reduced corneal thinning compared to controls.
Conclusions:
- Nanostructured hydroxyapatite-titanium coatings enhance substrate bonding and tissue integration.
- Aerosol-deposited nanostructured HA-titanium is a promising material for keratoprosthesis.
- This approach offers potential for improved treatment of corneal blindness.
