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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
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Morbidity and mortality in children with obstructive sleep apnoea: a controlled national study

Poul Jennum1, Rikke Ibsen, Jakob Kjellberg

  • 1Department of Clinical Neurophysiology, Danish Center for Sleep Medicine, , Glostrup, Denmark.

Thorax
|June 11, 2013
PubMed

Insights

Children diagnosed with obstructive sleep apnoea (OSA) experience significant health issues years before and after diagnosis. This condition is linked to increased morbidity and a higher mortality rate compared to their peers.

Area of Science:

  • Pediatric Pulmonology
  • Sleep Medicine
  • Epidemiology

Background:

  • Obstructive sleep apnoea (OSA) in children is not well understood regarding diagnostic patterns.
  • There is a need to evaluate the morbidity and mortality associated with childhood OSA.

Purpose of the Study:

  • To investigate the diagnostic patterns of obstructive sleep apnoea (OSA) in children.
  • To evaluate the association of childhood OSA with morbidity and mortality.

Main Methods:

  • A cohort of 2998 children (aged 0-19) diagnosed with OSA was identified from the Danish National Patient Registry.
  • 11,974 matched controls were selected based on age, sex, and socioeconomic status.

Main Results:

  • Patients with OSA exhibited increased morbidity in the 3 years preceding diagnosis, including infections, endocrine, nervous, eye, ENT, respiratory, gastrointestinal, skin, and congenital conditions.
  • Post-diagnosis, OSA was linked to higher incidences of endocrine, nervous, ENT, respiratory, skin, musculoskeletal, congenital diseases, and abnormal clinical findings.
  • The 5-year mortality rate was significantly higher in children with OSA (70 per 10,000) compared to controls (11 per 10,000), with a hazard ratio of 6.58.

Conclusions:

  • Childhood obstructive sleep apnoea (OSA) is associated with substantial morbidity that manifests years before and persists after diagnosis.
  • OSA in children significantly increases the risk of mortality.
Abstract

Keywords:
Health EconomistSleep apnoea

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