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Updated: May 10, 2026
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Adenomatoid odontogenic tumor: a case report with immunohistological profile
Francesca Angiero1, Rolando Crippa
1Ospedale San Martino, Largo R Benzi, 10 Genova Italy. f.angiero@teos.it.
Unlabelled:
The adenomatoid odontogenic tumor (AOT) is an uncommon tumor of odontogenic origin, composed of odontogenic epithelium and characterized by slow but progressive growth. We report a rare case of AOT in an 18-year-old, who presented with a palpable bony-hard swelling in the anterior maxillary region. The tumor was radiographically well-defined, and exhibited unilocular radiolucency. Histologically, the appearance was of solid nodules of cuboid or columnar cells of odontogenic epithelium, forming typical nests or duct-like structures. Immunohistochemistry was positive for cytokeratins (CK) CK5/6, CK17, CK19 and negative for KI-67. The results were consistent with a diagnosis of AOT.
Conclusion:
A case of AOT is presented, emphasizing on the importance of recognizing neoplasms arising in odontogenic tissues. Recurrences seldom occur, and surgical cure is recommended.
