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ACP and Surgicel in bone hemostasis. A comparative experimental and histologic study
T Mattsson1, G Anneroth, P A Köndell
1Department of Oral Surgery, School of Dentistry, Karolinska Institutet, Stockholm, Sweden.
Swedish Dental Journal
|January 1, 1990
Summary
Absorbable collagen paste (ACP) and Surgicel are effective hemostatic agents for bone tissue. Both materials showed uneventful healing, with complete resorption and bone regeneration observed within 8 weeks.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Regenerative Medicine
Background:
- Developing biodegradable hemostatic agents for bone regeneration is crucial.
- Absorbable collagen paste (ACP) is a novel hemostatic agent.
- Surgicel is a widely used hemostatic agent in clinical practice.
Purpose of the Study:
- To compare the tissue response of ACP versus Surgicel during mandibular bone healing in rabbits.
- To evaluate the efficacy and resorption characteristics of these hemostatic agents.
- To assess the impact on bone healing progression.
Main Methods:
- Surgical implantation of ACP and Surgicel into mandibular bone defects in New Zealand white rabbits.
- Histological and macroscopic evaluation of tissue response at 1, 2, 4, and 8 weeks post-implantation.
- Assessment of bone healing and material resorption over the observation period.
Main Results:
- Both ACP and Surgicel facilitated uneventful bone healing, comparable to natural healing.
- A slight retardation in healing was observed with both agents compared to controls.
- Complete resorption of both hemostatic agents occurred within 4-8 weeks.
- Bone healing was completed by the end of the 8-week observation period.
Conclusions:
- ACP and Surgicel are safe and effective biodegradable hemostatic agents for bone defect management.
- These agents support bone regeneration and are fully resorbed, indicating good biocompatibility.
- Further clinical studies may be warranted to confirm these findings in human patients.