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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...

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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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SVGenes: a library for rendering genomic features in scalable vector graphic format.

Graham J Etherington1, Daniel MacLean

  • 1The Sainsbury Laboratory, Norwich Research Park, Norwich, NR4 7UH, UK.

Bioinformatics (Oxford, England)
|June 11, 2013
PubMed
Summary

SVGenes is a Ruby library that generates genomic visualizations using Scalable Vector Graphics (SVG). It offers a flexible interface for creating publication-quality figures and interactive web graphics of genomic data.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Data Visualization

Background:

  • Genomic data visualization is crucial for understanding biological information.
  • Scalable Vector Graphics (SVG) offers advanced features for interactive and high-quality graphics.
  • Existing methods may require data conversion for visualization.

Purpose of the Study:

  • To develop a flexible Ruby library for generating genomic visualizations.
  • To leverage SVG for creating publication-quality and interactive genomic figures.
  • To provide a tool that does not require pre-conversion of genomic data formats.

Main Methods:

  • Developed SVGenes, a Ruby-language library utilizing SVG primitives.
  • Implemented a Page object to manage horizontal Track objects.
  • Modeled genomic entities (genes, transcripts, histograms) as Glyph objects within tracks.

Main Results:

  • SVGenes renders genomic features using SVG primitives through a simple Ruby interface.
  • The library supports flexible styling and positioning of genomic elements within tracks.
  • It generates graphics for diverse genomic datasets without format conversion.

Conclusions:

  • SVGenes provides an effective solution for visualizing genomic data.
  • The library facilitates the creation of interactive and publication-ready genomic figures.
  • Its flexibility and ease of use make it valuable for bioinformatics and web applications.