Related Experiment Video
Updated: May 10, 2026

08:50
How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants
Published on: December 14, 2014
The moral case for the clinical placebo
Azgad Gold1, Pesach Lichtenberg
1Department of Psychiatry, Herzog Hospital, , Jerusalem, Israel.
Journal of Medical Ethics
|June 11, 2013
Summary
The ethical use of placebos in medicine is debated, but this study argues that intentional placebo administration can be morally acceptable under specific conditions, challenging concerns about patient autonomy.
Area of Science:
- Medical Ethics
- Clinical Pharmacology
- Biopsychosocial Medicine
Background:
- Placebos are historically common but ethically contentious due to deception and autonomy concerns.
- Current medical practice faces a dilemma regarding the ethical implications of placebo use.
Purpose of the Study:
- To examine the definition and clinical efficacy of placebos from a biopsychosocial viewpoint.
- To argue for the moral acceptability of intentional placebo use in certain clinical contexts.
- To clarify ethical definitions of lying and deception in relation to placebo administration.
Main Methods:
- Biopsychosocial analysis of placebo definition and efficacy.
- Ethical examination of lying, deception, and patient autonomy.
- Application of virtue-based ethics to placebo use.
Main Results:
- The intentional use of placebos can be morally acceptable under specific conditions.
- Concerns regarding patient autonomy may be overstated in the context of placebo administration.
- A virtue-based ethical framework supports the beneficent use of placebos.
Conclusions:
- Re-evaluating the ethical framework for placebo use is necessary.
- The clinical application of placebos requires careful consideration of ethical guidelines and patient well-being.
- A nuanced understanding of deception and autonomy supports the judicious use of placebos.
More Related Videos
Related Concept Videos
The Placebo Effect
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
Blinding
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
Blind Procedures
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...
Clinical Trials
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Ethics and Bioethics
Ethics is a philosophical study of moral actions. Ethics attempts to determine what is valuable for individuals and society. It examines the rational justification of moral judgments and analyzes what is morally just, fair, and right. Bioethics is a sub-discipline of applied ethics that analyzes the philosophical, social, and legal issues in life sciences and medicine. Ethical theories serve as a foundation for decision-making and represent the viewpoints from which people seek direction. They...

