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Updated: May 10, 2026

An ELISA Based Binding and Competition Method to Rapidly Determine Ligand-receptor Interactions
Published on: March 14, 2016
Aromatic-aromatic interactions: analysis of π-π interactions in interleukins and TNF proteins
Vaideeswaran Sivasakthi1, Parimelzaghan Anitha, Kalavathi Murugan Kumar
1Bioinformatics Division, School of Biosciences & Technology, VIT University, Vellore-632014, India.
Abstract:
Aromatic-aromatic hydrogen bonds are important in many areas of chemistry, biology and materials science. In this study we have analyzed the roles played by the π-π interactions in interleukins (ILs) and tumor necrosis factor (TNF) proteins. Majority of π-π interacting residues are conserved in ILs and TNF proteins. The accessible surface area calculations in these proteins reveal that these interactions might be important in stabilizing the inner core regions of these proteins. In addition to π-π interactions, the aromatic residues also form π-networks in ILs and TNF proteins. The results obtained in the present study indicate that π-π interactions and π-π networks play important roles in the structural stability of ILs and TNF proteins.
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