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Updated: May 10, 2026
07:44
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Translational models of ocular disease
1Section of Comparative Medicine, Yale University School of Medicine, 375 Congress Ave, New Haven, CT 06520, USA. caroline.zeiss@yale.edu
Veterinary Ophthalmology
|June 12, 2013
Summary
Animal models, particularly mice, are crucial for advancing human and veterinary medicine by studying shared ocular diseases. Research in these models informs treatments for conditions like glaucoma and retinal dystrophies in both humans and animals.
Area of Science:
- Comparative ophthalmology
- Translational research
- Genetics in animal models
Background:
- Animals serve as vital models for translating basic research into human therapeutics.
- Human medicine advancements frequently guide veterinary clinical practices.
- Ocular diseases present significant challenges in both human and animal health.
Purpose of the Study:
- To introduce key experimental animal models in ocular research.
- To emphasize the genetic contributions of the mouse model.
- To explore how studying shared ocular conditions across species informs research and treatment.
Main Methods:
- Review of key experimental model species, focusing on the mouse.
- Description of animal models' roles in specific ocular research areas.
- Emphasis on conditions common to humans and domestic animals.
Main Results:
- Mice are highlighted for their genetic contributions to ocular research.
- Animal models are discussed for their utility in studying intraocular neoplasia, corneal diseases, cataracts, uveitis, glaucoma, and retinal dystrophies.
- The interconnectedness of research findings across human, domestic, and laboratory animals is explored.
Conclusions:
- Comparative studies of ocular diseases in humans and animals enhance understanding and therapeutic development.
- The mouse model offers significant genetic insights for ocular research.
- Collaborative research across species accelerates progress in ophthalmology.
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