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Updated: May 10, 2026

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities
Published on: October 27, 2023
A spectrum of SPECT/CT image fusion applications in daily clinical practice
Stephen B Hobbs1, Bryan W Hamon, M Elizabeth Oates
1Department of Radiology, University of Kentucky, Lexington, KY 40536, USA. stephenhobbs.md@gmail.com
Abstract:
Direct multimodality image correlation optimizes interpretation and diagnostic confidence, thereby enriching the radiologist's role in guiding clinical management. The primary advantages of SPECT/CT image fusion are more accurate identification and localization of disease and improved specificity. As illustrated here, software-based SPECT/CT image fusion enhances diagnosis for a variety of clinical presentations using the armamentarium of common radiopharmaceuticals, but without the costs of hybrid systems.
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