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Updated: May 10, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
Tumor-induced host immunosuppression: special focus on CLL
1University of Nebraska at Omaha, Department of Biology, Omaha, NE 68182-0040, USA. ccutucache@unomaha.edu
Abstract:
Malignant cells are able to suppress host immune responses in an effort to avoid immune detection in vivo. Tumor-induced immunosuppression can be achieved at the molecular, cellular, and/or physiological levels. Herein the contribution of immune-tolerant genes and regulatory cells to immunosuppression related to alterations of T-cells and antigen-presentation is reviewed. Furthermore, key advances in countering tumor-induced immunosuppression are described in reference to immune evasion mechanisms used by chronic lymphocytic leukemia (CLL) cells. Lastly, the challenges associated with targeting the tumor microenvironment coupled with the usefulness of immunomodulatory drugs are discussed. This review summarizes select immune evasion tactics orchestrated by the conversation between CLL cells and their microenvironment.
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