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A simple method for computing acid-base state.

J P Blackburn, T D Preston, D A Strickland

    British Journal of Anaesthesia
    |April 1, 1975
    PubMed
    Summary
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    This study presents simple methods for calculating Siggaard-Andersen nomogram variables using pH, Pco2, and hemoglobin measurements. The derived calculations offer sufficient accuracy for clinical applications.

    Area of Science:

    • Clinical Chemistry
    • Acid-Base Balance

    Background:

    • The Siggaard-Andersen nomogram is crucial for acid-base balance assessment.
    • Accurate determination of nomogram variables is essential for clinical interpretation.

    Purpose of the Study:

    • To describe simple methods for computing Siggaard-Andersen nomogram variables.
    • To validate the accuracy of these methods for clinical use.

    Main Methods:

    • Utilizing direct measurement or calculation from pH, Pco2, and hemoglobin.
    • Applying the pH-log Pco2 buffer line equation and Henderson-Hasselbalch equation.
    • Employing derived polynomial equations for specific variable calculations.

    Main Results:

    • Established methods for calculating buffer line slope (S), SL, and SH.

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  • Provided an equation to determine hemoglobin concentration.
  • Demonstrated sufficient accuracy for clinical purposes.

    • Conclusions:

    • The described methods offer a simplified approach to Siggaard-Andersen nomogram variable computation.
    • These methods ensure reliable results for clinical decision-making in acid-base status assessment.