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Related Experiment Video

Updated: Apr 13, 2026

Detecting Glycogen in Peripheral Blood Mononuclear Cells with Periodic Acid Schiff Staining
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Multiple sclerosis and macrocytosis.

R F Crellin1, T Bottiglieri, E H Reynolds

  • 1Department of Neurology, King's College Hospital London, England.

Acta Neurologica Scandinavica
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis patients exhibit mild macrocytosis, a condition of larger red blood cells. This finding suggests a potential link to vitamin B12 metabolism issues in multiple sclerosis.

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Area of Science:

  • Neurology
  • Hematology

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease.
  • Macrocytosis, characterized by larger-than-normal red blood cells, is not a typical hallmark of MS.

Purpose of the Study:

  • To investigate the prevalence and significance of macrocytosis in patients with multiple sclerosis.
  • To explore potential underlying causes for observed macrocytosis in MS patients.

Main Methods:

  • Comparison of red blood cell indices in 27 multiple sclerosis patients against a matched neurological control group.
  • Evaluation against standard laboratory reference ranges.

Main Results:

  • Patients with multiple sclerosis demonstrated mild but statistically significant macrocytosis.
  • The cause of this macrocytosis remains undetermined.

Conclusions:

  • The study identifies macrocytosis as a potential, albeit mild, hematological finding in multiple sclerosis.
  • Preliminary clinical observations suggest a possible role for vitamin B12 metabolism, binding, or transport disturbances.