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Updated: May 10, 2026

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
A sustainable two-phase procedure for V-catalyzed toluene oxidative bromination with H2O2-KBr
Pierluca Galloni1, Marco Mancini, Barbara Floris
1Department of Chemical Sciences and Technologies, University of Roma Tor Vergata, Via Ricerca Scientifica snc, Rome, 00133, Italy.
Abstract:
A sustainable V(V) and Mo(VI) catalysed two-phase procedure for bromination of toluene under quite mild conditions is proposed; H2O2 is the primary oxidant and KBr is the bromine source; metal precursors are commercially available salts. The reaction is efficient without any additional solvent. By using PhCH3 as a solvent/substrate good yields, together with interesting selectivity toward the formation of PhCH2Br, are obtained with both metal ions. Recycling of the catalytic phase is also possible. Useful information on the V-peroxido chemistry was obtained.
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