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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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Related Experiment Video

Updated: May 10, 2026

A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat
13:27

A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat

Published on: October 6, 2018

Liver transplantation: past, present and future.

Ali Zarrinpar1, Ronald W Busuttil

  • 1Ronald Reagan UCLA Medical Center, Division of Liver and Pancreas Transplantation, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Los Angeles, CA 90095-7054, USA.

Nature Reviews. Gastroenterology & Hepatology
|June 12, 2013
PubMed
Summary

Liver transplantation has evolved from experimental to standard care for end-stage liver disease, with survival rates exceeding 80%. Ongoing challenges include organ shortages and managing complex patient conditions.

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Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

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Related Experiment Videos

Last Updated: May 10, 2026

A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat
13:27

A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat

Published on: October 6, 2018

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
08:54

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

Area of Science:

  • Hepatology and Transplant Surgery

Background:

  • Liver transplantation has advanced significantly since the first human operation in 1963.
  • Early challenges included organ quality, patient selection, surgical management, immunosuppression, and infections.

Approach:

  • This perspective summarizes the historical transformation of liver transplantation.
  • It details advancements in key areas that improved outcomes.

Key Points:

  • Liver transplantation is now a standard treatment for end-stage liver disease and certain cancers.
  • Survival rates exceed 80% at one year, with programs worldwide.
  • Current challenges include donor organ shortages, sicker recipients, retransplantation needs, immunosuppression toxicities, obesity, NASH, HCV recurrence, and hepatocellular carcinoma biology.

Conclusions:

  • Liver transplantation has transformed from an experimental procedure to a life-saving therapy.
  • Despite successes, significant challenges remain, requiring continued research and innovation.