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Updated: Aug 18, 2026

Murine Fetal Echocardiography
Published on: February 15, 2013
Two-tier approach to biophysical assessment of the fetus
The biophysical profile score is widely accepted as a superior predictor of acute-on-chronic fetal asphyxia over the nonstress test. Nevertheless, in the United Kingdom facilities for assessment of high-risk pregnancies by nonstress test are more widely available than with the biophysical profile score. After a retrospective review of 2038 biophysical assessments in 500 high-risk pregnancies, it is suggested that biophysical evaluation of the fetus can be rationalized on the basis of the clinical problem and fetal growth. Terminal acute-on-chronic fetal asphyxia can be excluded by a two-tier method of fetal assessment by initial nonstress test backed up by the biophysical profile score when the nonstress test is suboptimal.
The biophysical profile score is widely accepted as a superior predictor of acute-on-chronic fetal asphyxia over the nonstress test. Nevertheless, in the United Kingdom facilities for assessment of high-risk pregnancies by nonstress test are more widely available than with the biophysical profile score. After a retrospective review of 2038 biophysical assessments in 500 high-risk pregnancies, it is suggested that biophysical evaluation of the fetus can be rationalized on the basis of the clinical problem and fetal growth. Terminal acute-on-chronic fetal asphyxia can be excluded by a two-tier method of fetal assessment by initial nonstress test backed up by the biophysical profile score when the nonstress test is suboptimal.

