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Updated: May 10, 2026

Fabrication and Characterization of Griffithsin-modified Fiber Scaffolds for Prevention of Sexually Transmitted Infections
12:21

Fabrication and Characterization of Griffithsin-modified Fiber Scaffolds for Prevention of Sexually Transmitted Infections

Published on: October 31, 2017

Electrospun antibacterial chitosan-based fibers.

Milena Ignatova1, Nevena Manolova, Iliya Rashkov

  • 1Institute of Polymers, Laboratory of Bioactive Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria.

Macromolecular Bioscience
|June 12, 2013
PubMed
Summary

Chitosan

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Chitosan, a natural polysaccharide, exhibits inherent antibacterial properties due to its polycationic structure.
  • Its biocompatibility, non-toxicity, and biodegradability make it a valuable biomaterial.
  • Combining chitosan's attributes with nanofibrous materials offers advanced biomedical potential.

Purpose of the Study:

  • To review recent advancements in preparing antibacterial fibrous materials using chitosan and its derivatives.
  • To explore various fabrication techniques for chitosan-based antibacterial materials.
  • To highlight the integration of drugs and nanoparticles for enhanced functionality.

Main Methods:

  • Electrospinning of chitosan and its derivatives to create nanofibrous scaffolds.
Keywords:
antibacterial activitybiomaterialschitosanelectrospinninghybrid nanofibers

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  • Coating techniques for imparting antibacterial properties to existing materials.
  • Electrospinning-electrospraying for composite material fabrication.
  • Incorporation of bioactive nanoparticles and drugs into chitosan matrices.

    • Main Results:

    • Electrospun chitosan nanofibers demonstrate significant antibacterial activity.
    • Surface modification and drug/nanoparticle loading enhance the efficacy of chitosan-based materials.
    • Various fabrication methods yield tunable properties for specific biomedical applications.

    Conclusions:

    • Chitosan-based fibrous materials are promising for developing advanced antibacterial solutions in biomedicine.
    • The combination of chitosan derivatives and nanofiber technology offers versatile platforms for drug delivery and tissue engineering.
    • Continued research into fabrication methods and functionalization is key to unlocking their full potential.