[Estimation of the healing process of denatured orthotopic bone implants in an animal model. I. Measurements with...

The paper gives in a series of 3 parts a survey, quantitative statements and conclusions on the healing process of denatured orthotopic osteoresections with the initial bone obtained by, polarization optical measurements (this first part), morphological evaluation method (part II), (in these cases the collagen polymorphism served as indicator for the regeneration course) and, semiquantitative method of observation after conventionally histological treatment as well (part III). The investigations were carried out on the mandible of pigs depending on the treatment of the resected bone parts (chemical or hyperthermal denaturation in comparison with the native state). Samples of osteoreimplantions were taken in intervals of one week up to the 70th postoperative day. Histological sections were used from the different regions (contact region, gap region, border and internal regions of the resections) and investigated by the methods mentioned above. The results of the first part (polarization microscopical measurements) revealed the regular course of differentiation in the bone regeneration process: The resection is fully integrated into the initial bone after a mean duration of 112 +/- 25 days. The fastest regeneration takes place in the contact region, the slowest is found within the resection (in the case of chemical denaturation investigated).