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Protein tyrosine phosphatases as novel targets in breast cancer therapy

Caroline E Nunes-Xavier1, Jorge Martín-Pérez, Ari Elson

  • 1BioCruces Health Research Institute, Hospital de Cruces, Plaza Cruces s/n, 48903 Barakaldo, Spain.

Biochimica Et Biophysica Acta
|June 13, 2013
PubMed

Insights

Protein tyrosine phosphatases (PTPs) regulate protein tyrosine kinases (PTKs) in breast cancer. Understanding PTPs offers new therapeutic strategies targeting oncogenic pathways in breast cancer.

Area of Science:

  • Oncology
  • Biochemistry
  • Molecular Biology

Background:

  • Breast cancer is associated with hyperactivated protein tyrosine kinases (PTKs).
  • Protein tyrosine phosphatases (PTPs) modulate PTK activity through dephosphorylation.
  • PTPs play a critical role in regulating oncogenic pathways involved in breast cancer cell growth.

Purpose of the Study:

  • To review the involvement of PTPs in breast cancer.
  • To highlight PTPs as key regulators of targeted PTKs in breast cancer therapy.
  • To discuss the implications of targeting PTPs for novel breast cancer treatments.

Main Methods:

  • Literature review of current knowledge on PTPs and PTKs in breast cancer.
  • Analysis of the functional interplay between PTPs and specific PTKs (e.g., HER1/EGFR, HER2/Neu, Src).
  • Discussion of therapeutic strategies targeting PTPs in breast cancer.

Main Results:

  • PTPs are major regulators of critical PTKs implicated in breast cancer.
  • Selective dephosphorylation by PTPs can activate or inactivate oncogenic signaling pathways.
  • The interplay between PTKs and PTPs is crucial for breast cancer progression.

Conclusions:

  • PTPs are significant players in breast cancer pathogenesis.
  • Targeting specific PTPs represents a promising avenue for novel breast cancer therapies.
  • Further research into PTP-PTK interactions can lead to more effective breast cancer treatments.
Keywords:
17β-estradiolAspBCBCCLBreast cancerCNSCell signalingCysDUSPDrug targetingE2EGFRERERKHERHGRIGF1RIRJAKJMMLJNKJanus kinaseLSMAPKNSPDGFRPRPTKPTPPTPN/NRPTPPTPR/RPTPProtein tyrosine kinaseProtein tyrosine phosphataseSFKSNPSTATSerSignal transducer and activator of transcriptionSrc-family kinaseTNBCTherapy resistanceThrTyrVEGFRaspartic acidbreast cancerbreast cancer cell linec-Jun N-terminal kinasecentral nervous systemcysteinedual specificity phosphataseepidermal growth factor receptorestrogen receptorextracellular-signal regulated kinasehormone growth receptorhuman epidermal growth factor receptorinsulin growth factor-like 1 receptorinsulin receptorjuvenile myeolomonocytic leukaemialeopard syndromemAbmTORmammalian target of rapamycinmitogen-activated protein kinasemonoclonal antibodynon-receptor PTPnoonan syndromeplatelet-derived growth factor receptorprogesterone receptorprotein tyrosine kinaseprotein tyrosine phosphatasereceptor-like PTPserinesingle-nucleotide polymorphismthreoninetriple negative breast cancertyrosinevascular–endothelial growth factor receptor

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