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Related Concept Videos

Ethics in Research01:56

Ethics in Research

Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Nurses' Legal Responsibilities I01:27

Nurses' Legal Responsibilities I

In healthcare, informed consent is a crucial process that involves thoroughly communicating medical treatment options to patients, including benefits, risks, potential side effects, and alternatives. This process enables patients to make well-informed decisions about their care, ensuring they understand the implications of their choices before consenting to or refusing treatment.
The legal responsibilities of a nurse regarding informed consent include the following:
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

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Related Experiment Video

Updated: May 10, 2026

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research
08:42

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research

Published on: July 31, 2017

Clarifying assent in pediatric research.

Noor A A Giesbertz1, Annelien L Bredenoord1, Johannes J M van Delden1

  • 1Department of Medical Humanities, Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands.

European Journal of Human Genetics : EJHG
|June 13, 2013
PubMed
Summary

Assent in research ethics is crucial for children. This study argues for personalized assent, focusing on researcher integrity rather than solely on autonomy or harm reduction.

Area of Science:

  • Bioethics
  • Pediatric Research Ethics
  • Human Genetics

Background:

  • Assent is increasingly cited in pediatric research and biobanking guidelines.
  • The conceptual underpinnings and ethical grounds for assent remain underexplored.
  • Existing frameworks often link assent to informed consent, potentially misaligning with childhood capacities.

Purpose of the Study:

  • To critically examine the ethical principles underlying assent in research.
  • To differentiate between assent derived from informed consent and engagement-based grounds.
  • To propose a refined model of assent tailored to the developmental specifics of children.

Main Methods:

  • Ethical analysis of assent principles.
  • Distinction between autonomy-based and engagement-based justifications for assent.

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  • Conceptualization of personalized assent.

    • Main Results:

    • Assent derived solely from informed consent lacks added value for children unable to make autonomous decisions.
    • Engagement grounds for assent better reflect the specifics of childhood.
    • Personalized assent, adjusted to the individual child, is proposed as a valuable approach.

    Conclusions:

    • The interpretation of assent should move beyond a mere extension of informed consent.
    • Engagement grounds offer a more appropriate ethical foundation for assent.
    • Personalized assent emphasizes researcher responsibility and respects the child's integrity.