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Related Concept Videos

Introduction to Connective Tissues01:11

Introduction to Connective Tissues

Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts, osteocytes,...
Dense Connective Tissue01:13

Dense Connective Tissue

Dense connective tissue contains more collagen fibers than loose connective tissue. As a consequence, it displays greater resistance to stretching. There are two major categories of dense connective tissue— regular and irregular.
Dense Regular Connective Tissue
In dense regular connective tissue, fibers are arranged parallel to each other, enhancing its tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular...
Overview of Connective Tissues Proper01:25

Overview of Connective Tissues Proper

Connective tissue proper is a class of connective tissue that encompasses all mature connective tissues except bone, cartilage, blood, and lymph. This extensive class of tissues has two subclasses — loose and dense connective tissues — classified based on the protein fiber arrangement and the amount of ground substance. 
The loose connective tissues have a meshwork of thin collagen and elastin fibers, which provide tensile strength for support and enough elasticity to move cells. They have...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Loose Connective Tissue01:26

Loose Connective Tissue

Loose connective tissue is found between many organs. Its main function is to absorb shock and bind tissues together. It also allows water, salts, and various nutrients to diffuse into cells that are embedded in it or present in adjacent tissues.
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
Functions of Connective Tissues01:17

Functions of Connective Tissues

Connective tissues perform a broad range of functions in the body. Their primary function is to connect and link different tissues in the body and act as packaging material between tissues. The areolar tissue, a connective tissue prototype, commonly cements various tissue types in diverse body organs. In contrast, adipose tissue cushions internal organs while insulating the body from heat loss.
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.

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Related Experiment Video

Updated: May 10, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

Connective tissue ulcers.

Ganary Dabiri1, Vincent Falanga

  • 1Department of Dermatology and Skin Cancer, Roger Williams Medical Center, 50 Maude Street, Providence, RI 02908, USA.

Journal of Tissue Viability
|June 13, 2013
PubMed
Summary
This summary is machine-generated.

Connective tissue disorders (CTD) can cause disabling lower extremity and digital ulcers. Current treatment guidelines are lacking, posing significant challenges for patients and healthcare providers.

Keywords:
Connective tissue diseaseConnective tissue ulcersUlcersVasculitis

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Area of Science:

  • Rheumatology
  • Dermatology
  • Vascular Medicine

Background:

  • Connective tissue disorders (CTD), also known as collagen vascular diseases, are inflammatory conditions.
  • Examples include rheumatoid arthritis, lupus erythematosus, and scleroderma.
  • Cutaneous manifestations are common in CTD, aiding in diagnosis.

Purpose of the Study:

  • To highlight the occurrence and challenges of lower extremity and digital ulcers in patients with CTD.
  • To underscore the lack of established diagnostic and treatment guidelines for these ulcers.
  • To emphasize the substantial morbidity and socioeconomic impact of CTD-related ulcerations.

Main Methods:

  • Review of existing literature on CTD and associated ulcerations.
  • Analysis of clinical presentations and complications.
  • Discussion of diagnostic and therapeutic challenges.

Main Results:

  • Lower extremity and digital ulcers are infrequent but disabling complications of long-standing CTD.
  • The exact frequency and multifactorial causes of these ulcers are not well-defined.
  • There are no established guidelines for the diagnosis and treatment of CTD-related ulcerations.

Conclusions:

  • CTD-associated ulcers represent a significant medical and economic burden.
  • Improved understanding and standardized approaches are needed for managing these intractable wounds.
  • Multidisciplinary wound healing centers play a crucial role in patient care.