Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hormones Regulating Blood Glucose

Hormones Regulating Blood Glucose

Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are co-secreted in...

Insulin Secretory Vesicles

Insulin Secretory Vesicles

Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...

B Cell Activation and Differentiation

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

Somatic to iPS Cell Reprogramming

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...

TGF - β Signaling Pathway

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates.

Molecular metabolism·2018

Same author

Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster.

Proceedings of the National Academy of Sciences of the United States of America·2017

Same author

Pancreatic α-cell hyperplasia and hyperglucagonemia due to a glucagon receptor splice mutation.

Endocrinology, diabetes & metabolism case reports·2016

Same author

GLP-1 Induces Barrier Protective Expression in Brunner's Glands and Regulates Colonic Inflammation.

Inflammatory bowel diseases·2016

Same author

Xenotropic retrovirus Bxv1 in human pancreatic β cell lines.

The Journal of clinical investigation·2016

Same author

Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo.

Molecular endocrinology (Baltimore, Md.)·2015

Search research articles

Related Experiment Video

Updated: May 10, 2026

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

Published on: July 16, 2016

Beta cell workshop 2013 Kyoto.

R Scott Heller¹, Ole D Madsen, Jens Høriis Nielsen

¹Imaging Group; Novo Nordisk; Måløv, Denmark.

|June 13, 2013

Summary

This summary is machine-generated.

The 8th Beta Cell Workshop in Kyoto brought together over 200 scientists to discuss pancreas function, development, and disease genetics. Key findings on beta cell research were presented, highlighting recent advancements in the field.

Keywords:

Kyoto alpha cells beta cells genetics islets pancreas regeneration signaling

More Related Videos

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

Published on: October 31, 2007

Related Experiment Videos

Last Updated: May 10, 2026

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

Published on: July 16, 2016

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

Published on: October 31, 2007

Area of Science:

Endocrinology and Metabolism
Cell Biology
Genetics

Background:

The 8th Workshop on Beta Cells convened in Kyoto, Japan, continuing a series of international meetings focused on pancreatic beta cell research.
The workshop featured over 200 attendees from 18 countries, fostering global collaboration in beta cell science.

Purpose of the Study:

To review and disseminate recent advancements in beta cell research presented at the 8th Workshop.
To cover diverse aspects of pancreas function, development, and the genetic basis of related diseases.

Main Methods:

The workshop included 47 main oral presentations and approximately 75 poster presentations.
Discussions and presentations covered a broad spectrum of beta cell biology and pathology.

Main Results:

The event showcased cutting-edge research on beta cell biology, function, and disease.
New insights into pancreas development and the genetic underpinnings of diseases affecting beta cells were shared.

Conclusions:

The 8th Beta Cell Workshop served as a vital platform for sharing the latest research findings and fostering future directions in beta cell science.
Continued international collaboration is crucial for advancing our understanding of beta cells and treating related metabolic disorders.