Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Production of Antibiotics

Production of Antibiotics

Penicillin, one of the earliest and most widely used antibiotics, is produced industrially by the filamentous fungus Penicillium chrysogenum. Large stirred-tank bioreactors ranging from tens to hundreds of thousands of liters maintain tightly controlled temperature, pH, and dissolved oxygen conditions to support fungal metabolism and maximize antibiotic yield. Penicillin is a secondary metabolite, synthesized primarily during the stationary growth phase, which requires a carefully managed...

Mechanism of Antibiotic Resistance in MRSA

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...

Clinical Significance of Antibiotic Resistance

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

Antibiotic Selection

Antibiotic Selection

Development of Antibiotic Resistance

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...

Inhibitors of Bacterial Protein Synthesis

Inhibitors of Bacterial Protein Synthesis

Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Siderophore-Antibiotic Heterodimer Imaging Agent Enables <i>In Vivo</i> PET Imaging of <i>S. aureus</i> Infections.

Journal of medicinal chemistry·2026

Same author

Evidence for C-Methylation Proceeding via a Cyclopropane Intermediate during Tabtoxin Biosynthesis.

ACS chemical biology·2026

Same author

Correction to "Identification and Characterization of the Biosynthesis of the Hybrid NRPS-NIS Siderophore Nocardichelin".

ACS chemical biology·2025

Same author

Covalent Irreversible Inhibitors of Tetracycline Destructases.

ACS infectious diseases·2025

Same author

3‑Hydroxy-Beta-Lactam Inhibitors of Dihydrofolate Synthetase.

ACS bio & med chem Au·2025

Same author

Identification and Characterization of the Biosynthesis of the Hybrid NRPS-NIS Siderophore Nocardichelin.

ACS chemical biology·2025

Search research articles

Related Experiment Video

Updated: May 10, 2026

Fission Yeast as a Platform for Antibacterial Drug Screens Targeting Bacterial Cytoskeleton Proteins

Fission Yeast as a Platform for Antibacterial Drug Screens Targeting Bacterial Cytoskeleton Proteins

Published on: April 26, 2024

Prospects for new antibiotics: a molecule-centered perspective.

Christopher T Walsh¹, Timothy A Wencewicz¹

¹Biological Chemistry and Molecular Pharmacology Department, Harvard Medical School, Boston, MA, USA.

The Journal of Antibiotics

|June 13, 2013

Summary

New antibiotic scaffolds are crucial to combat resistant pathogens. This study explores novel sources and strategies for discovering next-generation antibiotics, focusing on molecular frameworks and bacterial targets.

More Related Videos

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

Atomic Force Microscopy Combined with Infrared Spectroscopy as a Tool to Probe Single Bacterium Chemistry

Atomic Force Microscopy Combined with Infrared Spectroscopy as a Tool to Probe Single Bacterium Chemistry

Published on: September 15, 2020

Related Experiment Videos

Last Updated: May 10, 2026

Fission Yeast as a Platform for Antibacterial Drug Screens Targeting Bacterial Cytoskeleton Proteins

Fission Yeast as a Platform for Antibacterial Drug Screens Targeting Bacterial Cytoskeleton Proteins

Published on: April 26, 2024

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

Atomic Force Microscopy Combined with Infrared Spectroscopy as a Tool to Probe Single Bacterium Chemistry

Atomic Force Microscopy Combined with Infrared Spectroscopy as a Tool to Probe Single Bacterium Chemistry

Published on: September 15, 2020

Area of Science:

Microbiology
Medicinal Chemistry
Drug Discovery

Background:

Rising antibiotic resistance necessitates continuous discovery of new drugs.
Past successes relied on natural products and medicinal chemistry optimization.
There is an urgent need for novel antibiotic molecular frameworks.

Purpose of the Study:

To explore new sources for antibiotic molecular scaffolds.
To evaluate the potential of chemogenetic approaches in antibiotic discovery.
To identify bacterial targets for re-examination in antibiotic development.

Main Methods:

Molecule-centered perspective on scaffold discovery.
Analysis of chemogenetic strategies for antibiotic development.
Re-evaluation of existing bacterial targets for antibiotic intervention.

Main Results:

Identification of potential new sources for antibiotic scaffolds.
Assessment of the feasibility of chemogenetic approaches.
Prioritization of bacterial targets for future research.

Conclusions:

Novel molecular frameworks are essential for future antibiotic development.
Chemogenetic methods show promise for discovering new antibiotics.
Revisiting existing bacterial targets may yield new therapeutic strategies.