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Decrease in plasma adiponectin level and increase in adiponectin immunoreactivity in cortex and hippocampus after

Satoru Takeuchi1, Kojiro Wada, Hiroshi Nawashiro

  • 1National Defense Medical College, Department of Neurosurgery, Saitama, Japan. drne776@ndmc.ac.jp

Turkish Neurosurgery
|June 13, 2013
PubMed
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Plasma adiponectin levels decrease after traumatic brain injury (TBI) in rats. Adiponectin levels and brain immunoreactivity change, suggesting its role in TBI

Area of Science:

  • Neuroscience
  • Immunology
  • Endocrinology

Background:

  • Adiponectin is crucial for regulating tissue inflammation.
  • Plasma adiponectin levels decrease in acute illnesses, suggesting a role in inflammatory responses.
  • The role of adiponectin in traumatic brain injury (TBI) remains largely unknown.

Purpose of the Study:

  • To investigate changes in plasma adiponectin levels post-TBI.
  • To examine the brain's adiponectin immunoreactivity following TBI.

Main Methods:

  • Adult male Sprague-Dawley rats underwent lateral fluid percussion TBI.
  • Plasma adiponectin levels were quantified using ELISA.
  • Adiponectin immunoreactivity in brain tissue was assessed via immunohistochemistry and Western blot.

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Last Updated: May 10, 2026

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Published on: November 19, 2012

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
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Main Results:

  • Plasma adiponectin levels significantly decreased at 48 and 72 hours post-TBI.
  • Adiponectin immunoreactivity increased in the cerebral cortex at 24 hours post-TBI.
  • Adiponectin immunoreactivity increased in the hippocampus at 72 hours post-TBI.

Conclusions:

  • Adiponectin levels and brain expression are altered following TBI.
  • These findings suggest adiponectin participates in the pathophysiological processes of TBI.