Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro-<i>N</i>-(2'-methyl-3'-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1'-biphenyl]-4-yl)benzamide. Structure-Activity Relationship and Preclinical Characterization.

Journal of medicinal chemistry·2021
Same author

Cystotome or nonelectrocautery dilating catheters for fistula tract dilatation during endoscopic transmural drainage of pancreatic fluid collections.

Endoscopic ultrasound·2021
Same author

Perforations from Endoscopic Dilation of Corrosive Strictures in Adults: A Systematic Review and Meta-Analysis.

Digestive diseases and sciences·2021
Same author

Isolation, Docking and In Silico ADME-T Studies of Acacianol: Novel Antibacterial Isoflavone Analogue Isolated from Acacia leucophloea Bark.

Current drug metabolism·2021
Same author

Leveraging homologies for cross-species plasma proteomics in ungulates using data-independent acquisition.

Journal of proteomics·2021
Same author

Limited condylar mobility by ultrasonography predicts difficult direct laryngoscopy in morbidly obese patients: An observational study.

Indian journal of anaesthesia·2021
Same journal

To be an Intellectual of the Brain.

Turkish neurosurgery·2026
Same journal

In Memoriam: Professor M. Gazi Yaşargil.

Turkish neurosurgery·2026
Same journal

Madison Microneurosurgery Initiative: A Tribute to Professor M. Gazi Yaşargil's Legacy in Microvascular Surgery Training. Part II - Principles Applied and Practices Implemented.

Turkish neurosurgery·2026
Same journal

Madison Microneurosurgery Initiative: A Tribute to Professor M. Gazi Yaşargil's Legacy in Microvascular Surgery Training. Part I - A Brief History of Microsurgery and Yaşargil's Contributions.

Turkish neurosurgery·2026
Same journal

Professor Mahmut Gazi Yasargil: Memories from Little Rock 1994-2003.

Turkish neurosurgery·2026
Same journal

The Professor We Knew.

Turkish neurosurgery·2026
See all related articles

Related Experiment Video

Updated: May 10, 2026

Full Endoscopic Interlaminar Approach for Paracentral L5-S1 Disc Herniation
02:14

Full Endoscopic Interlaminar Approach for Paracentral L5-S1 Disc Herniation

Published on: April 14, 2023

Intradural disc herniation - a case report.

S K Jain1, I Vijay Sundar, Vinod Sharma

  • 1S.M.S Medical College and Hospital, Department of Neurosurgery, Jaipur, India. shashi_neelu@yahoo.com

Turkish Neurosurgery
|June 13, 2013
PubMed
Summary
This summary is machine-generated.

Intradural disc herniation is a rare spinal condition. Early diagnosis and surgical intervention are crucial for favorable outcomes in patients presenting with severe symptoms.

Related Experiment Videos

Last Updated: May 10, 2026

Full Endoscopic Interlaminar Approach for Paracentral L5-S1 Disc Herniation
02:14

Full Endoscopic Interlaminar Approach for Paracentral L5-S1 Disc Herniation

Published on: April 14, 2023

Area of Science:

  • Neurosurgery
  • Spinal Surgery
  • Radiology

Background:

  • Intradural disc herniation (IDH) is an uncommon spinal pathology, frequently observed in the lumbar region, specifically at the L4-L5 level.
  • Preoperative diagnosis of IDH often poses challenges, with many cases identified incidentally during surgery for presumed simple disc herniation.
  • Contrast-enhanced MRI is essential for accurate preoperative diagnosis of intradural disc herniation.

Observation:

  • A 40-year-old female presented with low back pain, bilateral lower limb pain, and urinary retention following a fall.
  • Initial unenhanced MRI indicated a large L4-L5 disc herniation; however, intraoperative findings revealed a hard intradural mass.
  • Surgical exploration identified a disc fragment within the dura mater, necessitating dural repair.

Findings:

  • The patient underwent L4 and L5 laminectomy, revealing a palpable intradural mass.
  • A rent in the anterior dura was discovered, through which a herniated disc fragment had protruded.
  • Surgical removal of the disc fragment and subsequent dural suturing led to a successful recovery.

Implications:

  • Intradural disc herniation should be considered in the differential diagnosis of prolapsed intervertebral disc disease, particularly with sudden symptom exacerbation.
  • A discrepancy between unenhanced MRI findings and intraoperative observations warrants high suspicion for IDH.
  • Prompt surgical management of IDH can lead to significant clinical improvement and positive patient outcomes.