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Hypertriglyceridemia accompanied by increased serum complement component 3 and proteinuria in non-nephrotic chronic

Kentaro Kohagura1, Masako Kochi, Tsuyoshi Miyagi

  • 1Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus School of Medicine, 207 Uehara, Nishihara-cho, Okinawa, 903-0215, Japan, kohagura@med.u-ryukyu.ac.jp.

Clinical and Experimental Nephrology
|June 13, 2013
PubMed

Insights

High triglycerides (hTG) combined with high complement component 3 (hC3) levels are linked to increased proteinuria in chronic kidney disease (CKD). Arteriolopathy may play a role in this association, warranting further investigation.

Area of Science:

  • Nephrology
  • Endocrinology
  • Immunology

Background:

  • Hypertriglyceridemia (hTG) is a known risk factor for chronic kidney disease (CKD) progression.
  • The role of adipocytokine complement component 3 (C3) in the hTG-CKD association is unclear.

Purpose of the Study:

  • To investigate the association between hypertriglyceridemia (hTG) and proteinuria in non-nephrotic chronic kidney disease (CKD).
  • To determine if elevated complement component 3 (C3) levels modify this association.

Main Methods:

  • Cross-sectional study of 138 non-nephrotic CKD patients with renal biopsy.
  • Assessed proteinuria, hTG, and high C3 levels (hC3, ≥ median).
  • Analyzed associations using logistic regression, adjusting for confounders and arteriolopathy.

Main Results:

  • Patients with hTG showed significantly higher urine protein levels.
  • High C3 (hC3+) alone was associated with increased proteinuria (OR 2.98).
  • The combination of hTG and hC3 (hTG+/hC3+) was strongly associated with proteinuria (adjusted OR 5.32), an association reduced by arteriolopathy.

Conclusions:

  • Hypertriglyceridemia (hTG) in the presence of high complement component 3 (hC3) is associated with proteinuria in non-nephrotic CKD.
  • Renal arteriolopathy may mediate this association.
  • Prospective studies are needed to confirm the predictive value for CKD progression.
Abstract

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