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Affective disorders in Parkinson's disease
Kelly S G Aminian1, Antonio P Strafella
1Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.
Current Opinion in Neurology
|June 13, 2013
Summary
Affective disorders are increasingly recognized as complications of Parkinson's disease. Advances in neuroimaging reveal widespread brain changes and offer potential for new therapeutic targets.
Area of Science:
- Neurology
- Neuroscience
- Psychiatry
Background:
- Nonmotor symptoms, including affective disorders, are increasingly recognized in Parkinson's disease (PD).
- Growing awareness and advanced neuroimaging tools are driving research into behavioral complications of PD.
- Functional connectivity changes in the basal ganglia and widespread brain alterations contribute to affective disorders in PD.
Purpose of the Study:
- To review recent literature on affective disorders associated with Parkinson's disease.
- To explore the neurobiological mechanisms underlying these disorders.
- To identify potential therapeutic targets and risk factors.
Main Methods:
- Literature review of recent studies on Parkinson's disease and affective disorders.
- Analysis of neuroimaging findings related to brain structure and function in PD patients.
- Examination of the role of dopaminergic treatments in behavioral symptoms.
Main Results:
- Parkinson's disease affects striatal and extrastriatal regions, altering gray matter, white matter, blood flow, and neurotransmitter function.
- Dopaminergic treatments can exacerbate or trigger behavioral symptoms in some individuals.
- Neuroimaging reveals alterations in functional connectivity and widespread brain changes contributing to affective disorders.
Conclusions:
- Neuroimaging enhances understanding of the mechanisms linking Parkinson's disease to behavioral disorders.
- Increased knowledge may lead to novel therapeutic targets and identification of individuals at risk.
- Identifying risk factors is crucial for developing preventive strategies and early treatment of susceptible individuals.
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