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A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

Published on: April 2, 2012

A case of late herpes simplex encephalitis relapse.

Andrea Rigamonti¹, Giuseppe Lauria, Vittorio Mantero

¹Department of Neurology, Alessandro Manzoni Hospital, Via Dell'Eremo 9/11, 23900 Lecco, Italy. rig74@libero.it

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology

|June 13, 2013

Summary

Late relapse of herpes simplex encephalitis, a rare condition, can occur years after the initial episode. This case highlights a patient experiencing a recurrence 8 years later, emphasizing the need for awareness of delayed herpes simplex encephalitis reactivation.

Keywords:

CPAP-NIV CSF CT EEG Encephalitis HIV HSE HSV Herpes simplex ICU MRI PCR PLEDs Relapse cerebrospinal fluid computed tomography continuous positive airways pressure non-invasive ventilation electroencephalography herpes simplex encephalitis herpes simplex virus human immunodeficiency virus intensive care unit magnetic resonance imaging periodic lateralized epileptic discharges positive polymerase chain reaction

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Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining

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Published on: January 23, 2014

Area of Science:

Neurology
Infectious Diseases

Background:

Herpes simplex encephalitis (HSE) is a severe brain infection.
Recurrence of HSE is uncommon, especially late relapses defined as occurring >3 months post-initial episode.

Observation:

A case of late relapse of herpes simplex encephalitis is presented in an adult.
The patient experienced the recurrent episode 8 years after the initial HSE at age 57.

Findings:

Late relapse of herpes simplex encephalitis is a rare but documented phenomenon.
This case represents an unusually long interval between initial HSE and late relapse.

Implications:

Highlights the importance of considering late HSE relapse in patients with neurological deterioration.
Suggests prolonged or intermittent viral shedding may occur in some individuals.
Underscores the need for further research into the mechanisms and management of late HSE recurrence.