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Updated: May 10, 2026

Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin
Published on: March 3, 2021
Abstract:
Recently, partially observable Markov decision processes (POMDP) solvers have shown the ability to scale up significantly using domain structure, such as factored representations. In many domains, the agent is required to complete a set of independent tasks. We propose to decompose a factored POMDP into a set of restricted POMDPs over subsets of task relevant state variables. We solve each such model independently, acquiring a value function. The combination of the value functions of the restricted POMDPs is then used to form a policy for the complete POMDP. We explain the process of identifying variables that correspond to tasks, and how to create a model restricted to a single task, or to a subset of tasks. We demonstrate our approach on a number of benchmarks from the factored POMDP literature, showing that our methods are applicable to models with more than 100 state variables.
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