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Updated: May 10, 2026

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
Published on: August 2, 2016
Acyloxymethyl esters of isophosphoramide mustard as new anticancer prodrugs
Joanna Cytarska1, Konrad Misiura, Beata Filip-Psurska
1Department of Chemical Technology of Pharmaceuticals, Collegium Medicum, Nicolaus Copernicus University, Jurasza 2, 85-094 Bydgoszcz, Poland. cytar@cm.umk.pl
Abstract:
A series of new prodrugs: [bis(2-chloroethylamino)phosphoryloxy]methyl acetate, [bis(2-chloroethylamino)phosphoryloxy]methyl pivalate and [bis(2-chloroethylamino)phosphoryloxy]methyl benzoate, was obtained in the reaction of isophosphoramide mustard (iPAM) with the corresponding acyloxymethyl halides. The cytotoxic activity of these new compounds is also shown. All compounds were highly active in the inhibition of cancer cell proliferation against the human lung (A594), prostate (PC-3) and breast (MCF-7) cancer cell lines.
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