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Updated: May 10, 2026

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants
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Array comparative genomic hybridization in pediatric acute leukemias.

Joanna Laskowska1, Joanna Szczepanek, Jan Styczyński

  • 1Department of Plant Physiology and Biotechnology, Nicolaus Copernicus University , Torun , Poland.

Pediatric Hematology and Oncology
|June 14, 2013
PubMed
Summary

Array comparative genomic hybridization (CGH) is a powerful tool for identifying biomarkers in acute leukemias. This technology aids in diagnosis, prognosis, and predicting treatment response in pediatric acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

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Area of Science:

  • Genomics
  • Oncology
  • Biomarker Discovery

Background:

  • Array comparative genomic hybridization (CGH) is a valuable technique for identifying novel biomarkers.
  • CGH-array technology offers high specificity, sensitivity, simplicity, and cost-effectiveness for clinical applications.

Purpose of the Study:

  • To review the diverse applications of CGH-array in pediatric acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
  • To highlight the role of CGH-array in advancing the diagnosis, prognosis, and personalized therapy prediction for acute leukemias.

Main Methods:

  • Review of current literature on CGH-array applications in pediatric acute leukemias.
  • Analysis of genomic alterations and molecular pathways in AML and ALL.

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Last Updated: May 10, 2026

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants
09:16

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Published on: February 21, 2015

Chromosome Preparation From Cultured Cells
07:42

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Published on: January 28, 2014

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
06:25

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Published on: February 6, 2012

Main Results:

  • CGH-array facilitates the identification of clinically relevant biomarkers in acute leukemias.
  • The technology supports precise diagnosis, prognostic assessment, and prediction of therapeutic response.

Conclusions:

  • CGH-array is a robust and versatile tool for clinical practice in pediatric hematologic malignancies.
  • Advancements in understanding genomic alterations with CGH-array improve patient outcomes in AML and ALL.