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Accidental overdose of insufflated colchicine
L R Baldwin1, R L Talbert, R Samples
1University of Texas, Austin.
Drug Safety
|July 1, 1990
Summary
Accidental nasal insufflation of colchicine powder, mistaken for methamphetamine, led to severe toxicity. This case highlights the dangers of misidentification and improper storage of potent medications.
Area of Science:
- Toxicology
- Pharmacology
- Emergency Medicine
Background:
- Colchicine, a potent medication for gout and other conditions, has a high potential for toxicity.
- Nasal insufflation is an uncommon route of administration, particularly for non-recreational drugs.
- Accidental ingestion or misuse of medications due to similar appearances is a known risk.
Observation:
- A 29-year-old man self-administered approximately 200mg of colchicine powder via nasal insufflation.
- The colchicine was mistaken for methamphetamine due to similar physical appearance and storage.
- Symptoms included gastrointestinal distress and myalgia within 24 hours of exposure.
Findings:
- The patient developed severe hypocalcemia, hypophosphatemia, and thrombocytopenia.
- These laboratory findings are consistent with colchicine toxicity.
- The patient required an 8-day hospitalization with supportive care and electrolyte replacement.
Implications:
- This case underscores the critical importance of secure medication storage and clear labeling.
- Healthcare providers should be aware of potential non-traditional routes of drug exposure and toxicity.
- Public awareness regarding the dangers of mistaking medications for illicit substances is crucial.