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Published on: June 8, 2022
[Subcutaneous teicoplanin for children with infectious endocarditis]
E Carpentier1, B Roméo, Y El Samad
1Pneumologie allergologie pédiatrique, pôle femme-couple-enfant, CHU d'Amiens, 80054 Amiens cedex 1, France.
Summary
Subcutaneous teicoplanin offers a viable alternative for prolonged antibiotic therapy in pediatric infectious endocarditis after initial intravenous treatment. This approach demonstrated effectiveness and safety in two pediatric cases, warranting further investigation.
Area of Science:
- Pediatric Infectious Diseases
- Pharmacology
- Cardiovascular Surgery
Background:
- Infectious endocarditis in children necessitates extended antibiotic treatment.
- Subcutaneous antibiotic administration, like teicoplanin, is an established alternative to intravenous therapy in adults.
Observation:
- Two pediatric patients with infectious endocarditis post-cardiac surgery received subcutaneous teicoplanin following initial intravenous antibiotics.
- Serum teicoplanin concentrations were therapeutic after dose adjustments for subcutaneous administration.
- No treatment-related adverse events were observed in the pediatric patients.
Findings:
- Subcutaneous teicoplanin was effective in treating infectious endocarditis in pediatric patients.
- Achieving and maintaining therapeutic serum concentrations is feasible with adjusted subcutaneous teicoplanin dosing.
Implications:
- Subcutaneous teicoplanin represents a potential option for prolonged antibiotic therapy in pediatric infectious endocarditis.
- Regular monitoring of antibiotic bioavailability is crucial for subcutaneous administration.
- Further randomized trials are needed to confirm the efficacy and safety of subcutaneous versus intravenous teicoplanin in children.
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