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[Subcutaneous teicoplanin for children with infectious endocarditis]

E Carpentier1, B Roméo, Y El Samad

  • 1Pneumologie allergologie pédiatrique, pôle femme-couple-enfant, CHU d'Amiens, 80054 Amiens cedex 1, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|June 14, 2013
PubMed

Insights

Subcutaneous teicoplanin offers a viable alternative for prolonged antibiotic therapy in pediatric infectious endocarditis after initial intravenous treatment. This approach demonstrated effectiveness and safety in two pediatric cases, warranting further investigation.

Area of Science:

  • Pediatric Infectious Diseases
  • Pharmacology
  • Cardiovascular Surgery

Background:

  • Infectious endocarditis in children necessitates extended antibiotic treatment.
  • Subcutaneous antibiotic administration, like teicoplanin, is an established alternative to intravenous therapy in adults.

Observation:

  • Two pediatric patients with infectious endocarditis post-cardiac surgery received subcutaneous teicoplanin following initial intravenous antibiotics.
  • Serum teicoplanin concentrations were therapeutic after dose adjustments for subcutaneous administration.
  • No treatment-related adverse events were observed in the pediatric patients.

Findings:

  • Subcutaneous teicoplanin was effective in treating infectious endocarditis in pediatric patients.
  • Achieving and maintaining therapeutic serum concentrations is feasible with adjusted subcutaneous teicoplanin dosing.

Implications:

  • Subcutaneous teicoplanin represents a potential option for prolonged antibiotic therapy in pediatric infectious endocarditis.
  • Regular monitoring of antibiotic bioavailability is crucial for subcutaneous administration.
  • Further randomized trials are needed to confirm the efficacy and safety of subcutaneous versus intravenous teicoplanin in children.
Abstract

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