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Related Concept Videos

Folliculogenesis01:20

Folliculogenesis

Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...

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Related Experiment Video

Updated: May 10, 2026

Isolation of Small Preantral Follicles from the Bovine Ovary Using a Combination of Fragmentation, Homogenization, and Serial Filtration
09:11

Isolation of Small Preantral Follicles from the Bovine Ovary Using a Combination of Fragmentation, Homogenization, and Serial Filtration

Published on: September 27, 2022

Gene Expression During Early Folliculogenesis in Goats Using Microarray Analysis.

Deborah M Magalhães-Padilha, Jane Geisler-Lee, Aurea Wischral

    Biology of Reproduction
    |June 14, 2013
    PubMed
    Summary
    This summary is machine-generated.

    This study reveals key gene expression changes during goat ovarian follicular development. Understanding these transcriptional profiles aids in identifying factors influencing oocyte survival and loss during follicle transitions.

    Keywords:
    bovine genome arrayfolliculogenesisgene expression profilinggoatovarian follicle development

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    Last Updated: May 10, 2026

    Isolation of Small Preantral Follicles from the Bovine Ovary Using a Combination of Fragmentation, Homogenization, and Serial Filtration
    09:11

    Isolation of Small Preantral Follicles from the Bovine Ovary Using a Combination of Fragmentation, Homogenization, and Serial Filtration

    Published on: September 27, 2022

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    07:03

    A Modified Co-Culture System for Understanding Granulosa-Theca Cell Interactions in the Bovine Ovary

    Published on: September 19, 2025

    Transcriptome Profiling of In-Vivo Produced Bovine Pre-implantation Embryos Using Two-color Microarray Platform
    09:04

    Transcriptome Profiling of In-Vivo Produced Bovine Pre-implantation Embryos Using Two-color Microarray Platform

    Published on: January 30, 2017

    Area of Science:

    • Reproductive Biology
    • Genomics
    • Molecular Endocrinology

    Background:

    • Ovarian follicular development involves complex gene expression and metabolic pathways.
    • Oocyte loss occurs during the transition from secondary to early tertiary follicles.
    • Understanding these dynamics is crucial for reproductive success and managing fertility.

    Purpose of the Study:

    • To investigate temporal changes in transcriptional profiles of caprine ovarian follicles.
    • To identify stage-specific gene expression patterns during the secondary to early tertiary follicle transition.
    • To elucidate the molecular mechanisms underlying follicular development and atresia in goats.

    Main Methods:

    • Microarray analysis of ovarian follicles from goats.
    • RNA extraction and cross-hybridization with a bovine gene array.
    • Identification of differentially expressed genes between follicle stages.

    Main Results:

    • 14,323 out of 23,987 bovine genes hybridized with goat mRNAs.
    • 2,466 stage-specific genes were identified as up- or down-regulated.
    • Significant differences in lipid metabolism, cell death, and hematological system pathways were observed.

    Conclusions:

    • This study identified critical genes and pathways involved in the transition from secondary to early tertiary follicles in goats.
    • The findings provide insights into the molecular regulation of follicular development and oocyte survival.
    • These results can inform future research on improving reproductive efficiency in livestock.