Light scattering by blood components after supplying glucose

Investigations were performed in order to find out whether the glucose concentration in liquids can be determined by means of light scattering. Both static light scattering and photon correlation spectroscopy (PCS) were used. Neither of them revealed a possibility of determination of glucose concentration in a pure glucose solution. But for glucose-protein-solutions a clear correlation between intensity of light scattering and glucose concentration was detected due to glycosylation of proteins. In blood serum it is solely possible to measure non-enzymatic reaction products between glucose and proteins and to determine the influence of Amadori products on protein structure. Therefore not even indirect conclusions on the present glucose concentration are possible.