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Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: lessons learned from first clinical
Marcella Franquesa1, Martin J Hoogduijn, Marlies E Reinders
1Transplantation and Nephrology, Erasmus MC, Rotterdam, The Netherlands. m.franquesa@erasmusmc.nl
Abstract:
The Fourth Expert Meeting of the Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Consortium took place in Barcelona on October 19 and 20, 2012. This meeting focused on the translation of preclinical data into early clinical settings. This position paper highlights the main topics explored on the safety and efficacy of mesenchymal stem cells as a therapeutic agent in solid organ transplantation and emphasizes the issues (proper timing, concomitant immunossupression, source and immunogenicity of mesenchymal stem cells, and oncogenicity) that have been addressed and will be followed up by the MiSOT Consortium in future studies.
Insights
Mesenchymal stem cells show promise for solid organ transplantation. The MiSOT Consortium is addressing key safety and efficacy issues for clinical translation, including timing, immunosuppression, and oncogenicity.
Area of Science:
- Immunology
- Regenerative Medicine
- Transplantation Science
Background:
- Mesenchymal stem cells (MSCs) are being investigated for their therapeutic potential in solid organ transplantation.
- Translating preclinical findings into clinical applications requires careful consideration of safety and efficacy.
- The Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Consortium aims to guide this translation.
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