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Updated: May 10, 2026

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
Published on: March 17, 2020
The evolution of the cancer niche during multistage carcinogenesis
Mary Helen Barcellos-Hoff1, David Lyden, Timothy C Wang
1The Department of Radiation Oncology, New York University School of Medicine, New York, New York 10016, USA. barcem01@nyumc.org
Abstract:
The concept of the tumour microenvironment recognizes that the interplay between cancer cells and stromal cells is a crucial determinant of cancer growth. In this Perspectives article, we propose the novel concept that the tumour microenvironment is built through rate-limiting steps during multistage carcinogenesis. Construction of a 'precancer niche' is a necessary and early step that is required for initiated cells to survive and evolve; subsequent niche expansion and maturation accompany tumour promotion and progression, respectively. As such, cancer niches represent an emergent property of a tumour that could be a robust target for cancer prevention and therapy.
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