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Updated: May 10, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Various cyclization scaffolds by a truly Ugi 4-CR.

Mantosh K Sinha1, Kareem Khoury, Eberhardt Herdtweck

  • 1University of Pittsburgh, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA.

Organic & Biomolecular Chemistry
|June 14, 2013
PubMed
Summary

Researchers developed novel heterocyclic scaffolds using a four-component Ugi reaction. This approach provides efficient access to diverse chemical structures for discovering new functional materials.

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