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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Do not underestimate nucleotide excision repair: it predicts not only melanoma risk but also survival outcome
Steffen Emmert1, Kenneth H Kraemer
1Department of Dermatology, Venerology, and Allergology, University Medical Center Göttingen, Göttingen, Germany.
Abstract:
Nucleotide excision repair (NER) removes UV-induced DNA damage and other bulky DNA lesions, thereby maintaining genomic integrity. Dr Qingyi Wei's group demonstrated over the last decade that NER fidelity and single-nucleotide polymorphisms (SNPs) in NER genes constitute melanoma risk biomarkers. In this issue, Li et al. provide evidence that SNPs in NER genes may also predict melanoma survival.
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