Related Experiment Video

Updated: May 10, 2026

Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells

Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells

Published on: September 5, 2017

Much remains to be learned about how UVR induces mutations

Thomas M Rünger¹

¹Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA. USA. truenger@bu.edu

The Journal of Investigative Dermatology

|June 14, 2013

Abstract:

Data on the wavelength dependence of UV-induced formation of DNA damage and skin cancer have been available for quite some time, but a detailed in vivo action spectrum of mutation formation has not yet been reported so far. This important information gap is filled by Ikehata et al. in this issue. Their findings question several aspects of our current thinking about UV-induced mutagenesis and carcinogenesis.

More Related Videos

Advanced Confocal Microscopy Techniques to Study Protein-protein Interactions and Kinetics at DNA Lesions

Advanced Confocal Microscopy Techniques to Study Protein-protein Interactions and Kinetics at DNA Lesions

Published on: November 12, 2017

The Lambda Select cII Mutation Detection System

The Lambda Select cII Mutation Detection System

Published on: April 26, 2018

Related Concept Videos

Mutations

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...

Mutations

Mutations

Mutations

Mutations

Nucleotide Excision Repair

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...

Nucleotide Excision Repair

Nucleotide Excision Repair

Nucleotide Excision Repair

Nucleotide Excision Repair

Articles linked to this work by shared authors, journal, and citation graph.

Ultraviolet Irradiation of Skin Cells.

Methods in molecular biology (Clifton, N.J.)·2026

The long non-coding RNA FLJ46906 binds to the transcription factors NF-κB and AP-1 and regulates expression of aging-associated genes.

Aging·2018

Mechanisms of Melanoma Promotion by Ultraviolet Radiation.

The Journal of investigative dermatology·2016

Longwave UV light induces the aging-associated progerin.

The Journal of investigative dermatology·2013

Primary cutaneous CD56 positive lymphoma: a diagnostic conundrum in an unusual case of lymphoma.

Journal of cutaneous pathology·2012

Comparison of DNA damage responses following equimutagenic doses of UVA and UVB: a less effective cell cycle arrest with UVA may render UVA-induced pyrimidine dimers more mutagenic than UVB-induced ones.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2011

See all related articles