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Related Concept Videos

Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Pedigree Analysis01:35

Pedigree Analysis

Overview
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...

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Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
09:16

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis

Published on: December 14, 2015

Basic genetics for dermatologists.

Muthu Sendhil Kumaran1, Dipankar De

  • 1Department of Dermatology, Venereology, and Leprology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Indian Journal of Dermatology, Venereology and Leprology
|June 14, 2013
PubMed
Summary
This summary is machine-generated.

Molecular genetics advances disease understanding, identifying over 350 monogenic skin diseases. This review provides essential genetics basics for dermatologists to improve diagnostic capabilities.

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Area of Science:

  • Medical Genetics
  • Dermatology
  • Molecular Biology

Background:

  • Molecular genetics has significantly advanced disease pathogenesis understanding, identification, and therapeutic interventions over recent decades.
  • The genetic basis for over 350 monogenic skin diseases has been identified in the last 20 years.
  • Despite advances, routine diagnostic use of molecular genetics in dermatology is limited by heterogeneity, access, and sensitivity.

Purpose of the Study:

  • To provide a foundational understanding of medical genetics for dermatologists.
  • To bridge the gap between genetic discoveries and clinical dermatological practice.
  • To enable dermatologists to better interpret and utilize genetic information in patient care.

Main Methods:

  • This study is a review of existing literature on molecular genetics and its application in dermatology.
  • The review focuses on fundamental genetic principles relevant to skin diseases.
  • Key genetic concepts and their clinical relevance are discussed.

Main Results:

  • Elucidation of the genetic underpinnings for a substantial number of monogenic skin conditions.
  • Identification of challenges hindering the routine clinical application of genetic testing in dermatology.
  • A framework for understanding the basics of medical genetics is presented.

Conclusions:

  • Molecular genetics offers powerful insights into skin disease mechanisms.
  • Enhanced dermatologists' understanding of genetics can improve diagnostic and therapeutic approaches.
  • Further integration of genetic knowledge into dermatological practice is warranted.