Related Experiment Video
Updated: May 10, 2026
07:29
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
[Complications of corneal cross-linking]
T G Seiler1, G Schmidinger, I Fischinger
1Institut für Refraktive und Ophthalmo-Chirurgie, Stockerstr. 37, 8002, Zürich, Schweiz. theo@seiler.tv
Summary
Complications from corneal cross-linking (CXL) for keratoconus are uncommon, occurring in 1-10% of cases. Management of rare CXL complications may necessitate keratoplasty.
Area of Science:
- Ophthalmology
- Corneal Surgery
Context:
- Corneal cross-linking (CXL) has been clinically available for over a decade.
- Indications and contraindications for CXL remain undefined.
- Understanding complication incidence is crucial for defining CXL guidelines.
Purpose:
- To review the incidence and types of complications associated with corneal cross-linking (CXL).
Summary:
- A literature search identified complication rates for CXL ranging from 1% to 10%, varying with keratoconus stage.
- Common early complications include stromal haze, sterile infiltrates, and delayed epithelial healing.
- Delayed stromal opacity and endothelium decompensation are also noted CXL complications.
Impact:
- Corneal cross-linking (CXL) complications are infrequent but can be severe.
- Some CXL complications may ultimately require corneal transplantation (keratoplasty).
- This data can inform the development of standardized CXL protocols and patient selection criteria.
Related Concept Videos
01:24Healing II: Complications
Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...