Related Experiment Video
Updated: May 10, 2026

Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients
Published on: March 29, 2022
Peripheral optical quality and myopia progression in children
Takefumi Yamaguchi1, Kazuhiko Ohnuma, Kenji Konomi
1Department of Ophthalmology, Tokyo Dental College, 5-11-13 Sugano, Ichikawa, Chiba, Japan, 272-8513, yama19770614@hotmail.com.
Insights
Peripheral optical quality does not predict myopia progression in children. Instead, hyperopic relative peripheral defocus (RPD) and focal line refraction are linked to axial elongation and myopic progression.
Area of Science:
- Ophthalmology
- Optometry
- Pediatric Eye Care
Background:
- Investigating peripheral optical quality and its link to axial elongation in pediatric myopia.
- Understanding factors influencing myopic progression in children is crucial for early intervention.
Purpose of the Study:
- To examine the relationship between peripheral optical quality and axial elongation in Japanese children.
- To determine if peripheral optical quality predicts myopic progression.
Main Methods:
- Twenty-nine Japanese children (10-12 years) with varying refractive errors were followed for 9 months.
- Peripheral point spread functions (PSFs) and modulation transfer function (MTF) area were measured to assess optical quality.
- Relative peripheral defocus (RPD) and focal line refractions were analyzed for correlation with myopia progression and axial length changes.
Main Results:
- Axial length changes correlated significantly with myopic progression and initial relative peripheral defocus (RPD).
- Children with significant myopic progression (>0.5 D) showed more hyperopic RPDs at 20° and 30° compared to non-progressors.
- No significant correlation was found between peripheral optical quality (MTF area) and myopia progression or axial elongation.
Conclusions:
- Hyperopic relative peripheral defocus (RPD) and focal line refraction are associated with axial myopia progression in children.
- Peripheral optical quality, as measured by MTF area, does not appear to be a predictor of myopic progression in this cohort.
- Findings suggest focusing on peripheral defocus characteristics for myopia management strategies.
Background:
To investigate the peripheral optical quality and its relationship with axial elongation, myopic progression in Japanese children.
Methods:
Twenty-nine Japanese children, ages 10 to 12 years old, with baseline refraction from +0.75 D to -5.5 D, were included and followed for 9 months. The central and peripheral point spread functions (PSFs; 0°, 10°, 20°, 30° nasally) were obtained at 0.25 D steps around ±2.5 D of best-focus PSF (BF-PSF) using double-pass PSF system. Modulation transfer function (MTF) area of the BF-PSF was calculated from BF-PSF to represent the peripheral optical quality. Relative peripheral defocus (RPD), the refraction of anterior/posterior focal lines, MTF area, and their correlations with myopia progression were analyzed.
Results:
The average refractive change in 9 months was -0.5 ± 0.8 D. The change in axial length was significantly positively correlated with the amount of myopic progression (P = 0.0058) and RPD (P = 0.0007, 0.0036 and 0.0040, at 10°, 20°, 30° respectively) at the initial visit, but did not correlate with the peripheral MTF area. Myopic progression of more than 0.5 D with axial elongation was observed in seven children (MP group). The RPDs at 20° and 30° in the MP group were significantly more hyperopic than in the non-MP group (P = 0.002 and 0.007), whereas there was no significant difference in axial length, and central and peripheral MTF area between the MP and non-MP groups. MP group had more hyperopic focal lines compared with non-MP group at 20° and 30°.
Conclusion:
These results suggest that the progression of axial myopia in children is associated with hyperopic RPD and refraction of focal lines, not with peripheral optical quality.
Related Concept Videos
Focusing of Light in the Eye
Photoreceptors and Visual Pathways
Glaucoma: Overview
Diabetic Retinopathy
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment

