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Cognitive outcomes following arterial ischemic stroke in infants and children

Christine A Hajek1, Keith Owen Yeates2, Vicki Anderson3

  • 1Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.

Journal of Child Neurology
|June 14, 2013
PubMed

Insights

Children with arterial ischemic stroke show lower cognitive function, especially in inhibitory control. Neurological function and lesion volume predict these cognitive outcomes, highlighting the impact of stroke on development.

Area of Science:

  • Pediatric Neurology
  • Neurodevelopmental Disorders
  • Cognitive Neuroscience

Background:

  • Pediatric arterial ischemic stroke (AIS) can impact neurodevelopment.
  • Cognitive deficits are common sequelae, but predictors require further investigation.

Purpose of the Study:

  • To investigate cognitive outcomes in children following AIS.
  • To explore predictors of cognitive dysfunction after pediatric AIS.

Main Methods:

  • 36 children with AIS and 15 controls (asthma) were assessed.
  • Cognitive ability, executive functions, and neurological function (Pediatric Stroke Outcome Measure) were evaluated.
  • MRI measured lesion location and volume.

Main Results:

  • Children with AIS scored in the low-average range for cognition.
  • AIS group showed significantly lower inhibitory control compared to controls.
  • Pediatric Stroke Outcome Measure and lesion volume negatively correlated with cognitive outcomes.

Conclusions:

  • Pediatric AIS is associated with cognitive impairments, particularly in executive functions.
  • Neurological deficits and stroke lesion characteristics are significant predictors of cognitive outcomes.
  • Early identification and intervention are crucial for managing cognitive sequelae in pediatric AIS.

Keywords:
Pediatric strokearterial ischemic strokeneuropsychological outcomes

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