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Dynamic host-bacteria interactions during an acidotic state induction.

Knut Rudi1

  • 1Hedmark University College, Hamar, Norway. Nofima Mat, Ås, Norway.

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Summary
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This study reveals key host-bacteria interactions in horses experiencing acidosis. Dynamic modeling identified Enterobacteriaceae and caecum lactate as crucial factors influencing serum lactate levels.

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Area of Science:

  • Equine gut microbiome research
  • Host-pathogen dynamics
  • Metabolic acidosis in animals

Background:

  • Limited time-series data hinders understanding of gut interactions leading to adverse states.
  • High hindgut fermentation can elevate serum lactate, a hallmark of acidosis.
  • Acidosis in horses is a significant concern impacting animal health.

Purpose of the Study:

  • To investigate dynamic host-bacteria interactions during induced acidosis in horses.
  • To identify key microbial and metabolic factors influencing serum lactate levels.
  • To model the complex interplay between gut environment and host physiological response.

Main Methods:

  • Time-series experiment involving oligofructose induction of acidosis in five horses.
  • Temporal measurements of host serum lactate, caecum bacteria, and metabolites.
  • Principal Component Analysis (PCA) and dynamic modeling for interaction analysis.

Main Results:

  • Equine hindgut streptococcal species (EHSS) positively correlated with caecum lactate and negatively with acetate.
  • Serum lactate showed significant interactions with caecum lactate and Enterobacteriaceae.
  • Enterobacteriaceae exhibited a positive interaction with serum lactate; serum-caecum lactate interaction was complex.
  • Individual variations in horse serum lactate were primarily explained by Enterobacteriaceae and caecum lactate levels.

Conclusions:

  • Dynamic models elucidated simple host-bacteria interactions driving serum lactate fluctuations.
  • Enterobacteriaceae and caecum lactate levels are critical determinants of serum lactate in horses.
  • Understanding these interactions is vital for managing and preventing acidosis in equine health.