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Renal Tubule and Collecting Duct

Renal Tubule and Collecting Duct

The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...

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Related Experiment Video

Updated: May 10, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

Procollagen I-expressing renin cell precursors.

Christian Karger¹, Felix Kurtz, Dominik Steppan

¹Institut für Physiologie, Universität Regensburg, Regensburg, Germany.

American Journal of Physiology. Renal Physiology

|June 14, 2013

Summary

Researchers identified potential precursor cells for renin-expressing cells in the kidney. These type I procollagen (PC1)-positive cells may reversibly switch to renin production, influenced by salt intake.

Keywords:

juxtaglomerular cell procollagen renin

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Last Updated: May 10, 2026

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Published on: October 26, 2020

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Published on: April 22, 2011

Area of Science:

Nephrology
Cell Biology
Developmental Biology

Background:

Renin-expressing cells are crucial for blood pressure regulation.
The precise origin and differentiation pathways of renin cells remain incompletely understood.
Identifying renin cell precursors is key to understanding kidney development and function.

Purpose of the Study:

To investigate the potential precursor stages of renin-expressing cells in the kidney.
To characterize cell types within perivascular cell clusters in aldosterone synthase-deficient mice.
To explore the relationship between cell phenotype, salt intake, and renin expression.

Main Methods:

Utilized aldosterone synthase-deficient mice as a model for renin cell overproduction.
Analyzed kidney tissue to identify and characterize cell populations.
Examined the expression of renin and type I procollagen (PC1) in perivascular cell clusters.
Correlated cell proportions with dietary salt intake.

Main Results:

Perivascular cell clusters in aldosterone synthase-deficient mice contained both renin-positive and PC1-positive cells.
Renin and PC1 expression appeared inversely related at the cellular level.
The ratio of renin-positive to PC1-positive cells decreased with increased salt intake, mirroring overall renin expression.
PC1-positive cells were also found in adult wild-type kidneys in juxtaglomerular areas.

Conclusions:

PC1-expressing cells in perivascular clusters may serve as precursors to renin-expressing cells.
These precursor cells exhibit reversible switching between PC1 and renin expression.
The findings provide insights into the dynamic nature of renin cell populations and their regulation by salt balance.