Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Haloperidol-induced torsades de pointes.

M Kriwisky¹, G Y Perry, D Tarchitsky

¹Heart Institute, Edith Wolfson Medical Center, Holon, Israel.

|August 1, 1990

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Myocardial Infarction in a Young Woman With Systemic Lupus Erythematosus Talma.

Angiology·2016

Same author

Acute myocardial infarction caused by coronary embolism complicated by left ventricular free wall rupture.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·2001

Same author

Unusual form of cardiac rupture: sealed subacute left ventricular free wall rupture, evolving to intramyocardial dissecting hematoma and to pseudoaneurysm formation--a case report and review of the literature.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·2001

Same author

Comparative effects of sodium bicarbonate and sodium chloride on reversing cocaine-induced changes in the electrocardiogram.

Journal of cardiovascular pharmacology·1999

Same author

Complete atrioventricular block complicating acute myocardial infarction in the thrombolytic era. SPRINT Study Group and the Israeli Thrombolytic Survey Group. Secondary Prevention Reinfarction Israeli Nifedipine Trial.

Journal of the American College of Cardiology·1999

Same author

Sudden death and cerebral anoxia in a young woman with congenital ostial stenosis of the left main coronary artery.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·1999

Psychotherapy with haloperidol can cause dangerous heart rhythms like torsades de pointes ventricular tachycardia. Stopping the drug and using isoproterenol reversed these effects, aiding understanding of sudden cardiac death risks.

Area of Science:

Cardiology
Psychopharmacology
Clinical Medicine

Background:

Haloperidol, an antipsychotic medication, is sometimes used in psychotherapy.
QT interval prolongation is a known risk factor for cardiac arrhythmias.
Torsades de pointes ventricular tachycardia is a life-threatening arrhythmia associated with QT prolongation.

Observation:

A patient undergoing psychotherapy experienced torsades de pointes ventricular tachycardia.
This event was temporally associated with the administration of conventional doses of haloperidol.
The patient's QT interval was significantly prolonged during the event.

Findings:

Cessation of haloperidol led to QT interval shortening.
Infusion of isoproterenol further facilitated QT interval normalization.

Related Experiment Videos

Torsades de pointes bursts resolved concurrently with QT interval shortening.

Implications:

This case highlights a potential mechanism linking haloperidol-induced QT prolongation to torsades de pointes.
Understanding this mechanism may inform risk assessment and management strategies for patients on haloperidol.
The findings contribute to the broader understanding of sudden cardiac death in patients receiving pharmacologic psychotherapy.