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Updated: May 10, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
A patient presenting with bilateral lung lesions, pleural effusion, and proteinuria
Katerina D Samara1, Giorgos Papadogiannis, Andrew G Nicholson
1Department of Thoracic Medicine, University of Crete, Medical School, 71110 Heraklion, Crete, Greece.
Abstract:
Diagnosis and management of a systemic vasculitis are among the most demanding challenges in clinical medicine. A patient with a past history of cryptogenic organizing pneumonia presents with new bilateral lung lesions, unilateral pleural effusion, and significant proteinuria. The patient tested p-ANCA and anti-MPO positive but c-ANCA negative. A diagnosis of granulomatosis with polyangiitis GPA was reached after performing both renal and lung biopsies. Step-by-step differential diagnosis and management are discussed.
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