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Avidity Studies in Anisakis simplex-Associated Allergic Diseases.

Carmen Cuéllar1, Ana Valls, Consolación de Frutos

  • 1Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.

Journal of Allergy
|June 14, 2013
PubMed
Summary

This study found differences in immunoglobulin avidity between gastroallergic anisakiasis and chronic urticaria. Factors like fish consumption and time since last infection influence these immune responses.

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Area of Science:

  • Immunology
  • Parasitology
  • Gastroenterology

Background:

  • Gastroallergic anisakiasis (GAA) and Anisakis-sensitization-associated chronic urticaria (CU+) are distinct conditions.
  • Previous research indicates differing specific IgE levels between GAA and CU+.

Purpose of the Study:

  • To investigate differences in immunoglobulin avidity (IgE and IgG) between GAA and CU+.
  • To explore the influence of time interval (TI) and fish consumption on these immunoglobulin avidities.

Main Methods:

  • Analysis of immunoglobulin levels and avidity indexes (AvIgE, AvIgG) in 16 GAA and 17 CU+ patients.
  • Utilized CAP analysis (Phadia) for immunoglobulin quantification.
  • Correlational and multivariate regression analyses were performed.

Main Results:

  • Higher IgG avidity was observed in GAA compared to CU+ (P = 0.035).
  • A trend towards lower IgE avidity was noted in GAA (P = 0.095).
  • AvIgG correlated positively with specific IgE, IgG, IgG4, and total IgE; AvIgE showed negative correlations with specific IgE, IgG4, and total IgE.

Conclusions:

  • Differential immunoglobulin isotype avidities exist between GAA and CU+.
  • Fish consumption and time since the last parasitic episode are significant factors influencing immunoglobulin avidity in these conditions.
  • Findings highlight distinct immune response patterns in Anisakis-related conditions.