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Modified chaihu shugan powder for functional dyspepsia: meta-analysis for randomized controlled trial.
Nan Yang1, Xuehua Jiang, Xuelan Qiu
1Department of Clinical Pharmacy & Pharmacy Administration, West China Pharmacy School, Sichuan University, No. 17 Section 3 Renmin Nanlu, Chengdu, Sichuan 610041, China.
Summary
Modified Chaihu Shugan powder (MCSP) shows promise for functional dyspepsia, improving symptoms alone or with prokinetic drugs. However, further high-quality trials are needed due to the risk of bias in current studies.
Area of Science:
- Gastroenterology
- Traditional Chinese Medicine
- Pharmacology
Background:
- Functional dyspepsia (FD) is a common gastrointestinal disorder.
- Modified Chaihu Shugan powder (MCSP) is a traditional Chinese herbal formula used for FD.
- The efficacy and safety of MCSP for FD require robust evidence.
Purpose of the Study:
- To systematically evaluate the effectiveness and safety of MCSP in treating FD.
- To compare MCSP with prokinetic drugs and MCSP combined with prokinetic drugs.
Main Methods:
- A meta-analysis of randomized controlled trials (RCTs) was conducted.
- Searched published and unpublished studies up to August 2012.
- Included RCTs comparing MCSP (alone or with prokinetics) versus prokinetics for FD patients.
Main Results:
- Twenty-two RCTs with 1998 participants were analyzed.
- MCSP significantly improved FD symptoms compared to prokinetic drugs alone (RR = 1.20).
- MCSP plus prokinetic drugs also showed significant improvement (RR = 1.18).
- No serious adverse events were reported.
Conclusions:
- MCSP, alone or combined with prokinetics, may be more effective than prokinetic drugs for FD.
- Current evidence is limited by the poor methodological quality and high risk of bias in included trials.
- Large-scale, high-quality RCTs are necessary to confirm these findings.