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Imputing amino acid polymorphisms in human leukocyte antigens

Xiaoming Jia1, Buhm Han, Suna Onengut-Gumuscu

  • 1Harvard-MIT (Massachusetts Institute of Technology) Division of Health Sciences and Technology, Boston, Massachusetts, United States of America.

Plos One
|June 14, 2013
PubMed
Summary

SNP2HLA is a computational tool that imputes human leukocyte antigen (HLA) alleles and amino acid variations from SNP data. Larger reference panels, not SNP density, are key for accurate HLA imputation in genetic studies.

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